Posters - COMPARISON OF THE INCIDENCE OF CONTACT LENS PAPILLARY CONJUNCTIVITIS BETWEEN SIX AND THIRTY NIGHT HIGH DK SOFT EXTENDED WEAR SCHEDULES.

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Posters

April 2003

COMPARISON OF THE INCIDENCE OF CONTACT LENS PAPILLARY CONJUNCTIVITIS BETWEEN SIX AND THIRTY NIGHT HIGH DK SOFT EXTENDED WEAR SCHEDULES.

J Stern, C Skotinsky, N O'Hare, J Tan, R Wong, D Sweeney, BA Holden,
Cooperative Research Centre for Eye Research and Technology, University of New South Wales

Purpose:

To determine the differences, if any, in the incidence and classification of Contact Lens Papillary Conjunctivitis (CLPC) with high Dk silicone hydrogel lenses worn on a six or thirty night extended wear schedule over a 24 month period.

Method:

In a prospective 24 month clinical trial, 85 subjects were randomly assigned to wear prototype high Dk soft contact lenses on a six night or thirty night extended wear schedule. The subjects were either previous six night low Dk extended wearers or previous low Dk daily wearers. The six night group cleaned and disinfected the lenses overnight after six nights extended wear and then reinserted the lenses. Both groups disposed of the lenses after thirty nights wear. CLPC was diagnosed by assessing tarsal conjunctival hyperemia, roughness and the presence of papillae. Hyperemia and roughness were graded on a scale where 0=none and 4= severe. The CLPC was classified as generalised when the papillae were scattered across the tarsus, and was classified as localised if the papillae were predominately in specific areas on the tarsus. Subjects were reviewed at one week, one month, three months and then at three monthly intervals until 24 months. The incidence was presented as the number of first events per one hundred eyes per year of lens wear. The differences between the two groups were assessed using analysis of variance.

Results:

The incidence of CLPC in 6NEW was 9 per 100 eye years (13 events) and the rate of CLPC in 30NEW was 5 per 100 eye years (6 events). The incidence of Generalised CLPC in 6NEW was 5 per 100 eye years (7 events) and in 30NEW group was 2 per 100 eye years (2 events). The incidence of localised CLPC in the 6NEW group was 7 per one hundred eye years (10 events) and the 30NEW group was 5 per 100 eye years (6 events). No differences existed in incidence of localised CLPC or generalised CLPC between the two groups. Four subjects in the 6N group and two subjects in the 30N group had episodes of both localised and generalised CLPC.

Conclusions:

There was no difference in the incidence of CLPC between the six and thirty night extended wear groups.

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COMPARISON OF THE INCIDENCE OF CONTACT LENS PAPILLARY CONJUNCTIVITIS BETWEEN SIX AND THIRTY NIGHT HIGH DK SOFT EXTENDED WEAR SCHEDULES - PDF - 89KB

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