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 Posters |
November 2003 |
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Duration of Discontinuation from
Silicone Hydrogel Extended Wear Due to Non Infectious Adverse
Responses
Katie Edwards, Thomas Naduvilath, Nina Tahhan,
Renee Du Toit, Eric Papas, Angela Kalliris, Jerome Ozkan, Deborah
F Sweeney . CCLRU,
School of Optometry and CRCERT, University of New South Wales, Kensington,
Australia. |
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| Purpose: |
| Most adverse ocular events (AE)
occurring with extended wear of silicone hydrogels resolve with
temporary discontinuation of lens wear. A retrospective study
to assess the average length of discontinuation due to AEs was
conducted. |
| Methods: |
| 282 subjects wore bilateral
silicone hydrogel lenses on a 30N EW schedule. Subjects were
reviewed at 1 night, 1 week, 1 month, then at 3 monthly intervals,
and if experiencing unusual signs or symptoms. If an AE was diagnosed,
lens wear was discontinued until the condition had completely
resolved. AEs were graded in severity on a scale of 1-4 and classified
as Corneal Inflammatory Events (CIE): Contact Lens Peripheral
Ulcer (CLPU), Contact Lens induced Acute Red Eye (CLARE), Infiltrative
Keratitis (IK), and Mechanical Events (ME): Superior Epithelial
Arcuate Lesion (SEAL), Corneal Erosion (CE). The length of discontinuation
due to different AEs was compared and the associations with severity
ratings and clinical variables examined. |
| Results: |
| On average, CIEs caused longer
durations of discontinuation (15±15 days) than MEs (5±3
days)(p<0.01). There were no differences in length of discontinuation
between different types of CIEs (CLPU: 11±8; CLARE: 12±8;
IK: 17±17; p=1.0), or between different types of MEs (SEAL:
5±4; CE: 5±3; p=1.0). Length of discontinuation
following CIEs, but not with MEs, correlated with severity rating
(r=0.46, p<0.01), density of infiltrate (r=0.27, p=0.04),
and depth of corneal staining (r=0.27, p=0.03). |
| Conclusions: |
| Most AEs with silicone hydrogels are self
limiting, with lens wear resuming on average within 15 days of
CIEs and 5 days of MEs. Denser infiltrates and deeper staining
in CIEs are associated with longer periods of discontinuation
from lens wear. |
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